The days of poor posture and worsening outlets have been forgotten. For over 99% of human history, hair loss has been an inevitable part of life. If you were to live long enough sooner or later, your hair, which is so dense and vibrant in young people, would be beautiful, maybe even a bit bare. Until recently, no one could predict the extent of the damage with certainty. Even today, there is more art than science to measure the rate, degree, and degree of alopecia that anyone will experience.
For a certain percentage of those affected, balding has never been a significant problem. Realizing that this was part of the normal aging process, they shrugged, sighed, and continued their activities. For others, hair loss has become the cornerstone of their lives, and many are desperate, and souls are poor to suicide. Patterned hair loss has also inspired a legion of developers to imagine solutions, some brilliant enough, some just bad.
For thousands of years, preparations have been made, haircuts and enchantments made to reverse the cruel tide. What was hard to grasp was a real cure. But as the saying goes, times change. Especially in the last twenty years, medicine has begun to meet its accumulated needs before we go into detail, some perspectives.
For the sake of brevity, today, we will discuss the three main ways of treating hair loss in the model style: cosmetic restoration, medical treatment, and surgical restoration. Cosmetic concealment involves two main approaches. The first is to dye the scalp or thicken the hair to hide the problem. Alternatively, non-living hair can be applied to the scalp in a particular way, e.g., with hairpieces or wigs.
Medical treatment includes the use of medicines or, more recently, naturally occurring reagents for the prevention of hair loss or thickening of endangered hair. These drugs or natural compositions may be taken orally or applied to the scalp, depending on their design.
Surgical recovery is a means of redistributing viable hairs forward and upward with the skin tissue of the sides and back of the scalp for a cosmetically improved appearance. It’s like using grass in your yard to fill the empty spaces of your garden. Each of these treatment options has its place, and each has its limits. Currently, no choice is suitable for everyone.
But in the coming years, the possibilities will undoubtedly improve. Much better. In the teaching of universities, private laboratories, and other institutions, research is now developing a legitimate treatment for hair loss. Considering the remaining space, this article discusses the two most likely approaches that bear fruit, gene therapy, and cloning hair. In the next decade, gene therapy will surely become one of the drug users of the 21st century.
In the little heart of the weakest and deadliest disease, genetic mutations do their dirty work. Many forms of cancer, age-related diseases, and yes, hair loss, though common, owe their pathogenesis to a genetic variation. Imagine genes as software that manages our body’s cellular material and begins to understand the concept of gene variation.
As our body cells age, they are often replaced. Copies of copies of transcripts are mostly error-free. But over time, genetic errors pile up. Some of these errors are relatively minor and are never noticed by us. Others are more serious. After all, the errors are so severe that a clinical disease occurs. Gene therapy is a methodology and a new medical discipline that systematically corrects genetic errors and restores the cellular mechanism for optimal performance.
Essential follicles have already been identified in the hair follicle that causes dysfunction of hair growth in pathological mutations. There are many diseases related to hair loss, and most of them are due to genetic factors. Generalized hair loss is a condition in which several genes effectively accumulate in the hair follicles of the scalp, causing them to die and fade. The correction of these genetic defects, gene by gene, occupies a prominent place in the list of molecular biologists who focus on the problem in question.
Hair cloning has a different approach: instead of reprogramming defective cell machinery, new hair follicles are developed as complete organic structures from a carefully selected population of stem cells in vitro. These stem cells are extracted from the remnants of viable donor hair and amplified under culture conditions to become numerous. The cells are then exposed to growth factors and other stimuli that produce whole hair follicles in a three-dimensional environment in vitro.
Eventually, if feasible, these newly developed hair follicles will be introduced into the nude areas of the scalp, where they presumably happily and energetically reproduce a healthy hair growth pattern. This incredible achievement requires a synthesis of molecular biology, proteomics, 3D tissue scaffolding, and other 21st-century science wonders. To name just one facet of this disturbing complexity, we need a very detailed understanding of the extracellular matrix protein dynamics to properly align the structural axis and polarity of the new hair follicle. Let us repeat this concept, but this time with a simple, if imperfect, analogy.
Imagine for a moment, and you want to make a new bulb of onion stem cells. During the process, you should probably make sure that the roots are pointing down and the stem up so that the onions are not planted upside down. Here the same principles apply. All parts must be set correctly for the machine to function correctly. With this rough analogy, we can begin to understand some of the challenges of three-dimensional work that do not occur when, for example, a single cell layer of cells is grown in a Petri dish.
Despite the enormous challenges, it is unlikely that one or both approaches will be the next generation of the next generation hair restoration method in the next decade.